The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations
Yamaguchi Tetsutaro, Kawaguchi Akira, 김용일, Haga Shugo, Katayama Koshu, Ishida Hajime, 박수병, Maki Koutaro, Kimur Ryosuke,
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( Yamaguchi Tetsutaro ) - Showa University School of Dentistry Department of Orthodontics
( Kawaguchi Akira ) - University of the Ryukyus Graduate School of Medicine Department of Human Biology and Anatomy
김용일 ( Kim Yong-Il ) - Pusan National University School of Dentistry Pusan National University Hospital Department of Orthodontics
( Haga Shugo ) - Showa University School of Dentistry Department of Orthodontics
( Katayama Koshu ) - Showa University School of Dentistry Department of Orthodontics
( Ishida Hajime ) - University of the Ryukyus Graduate School of Medicine Department of Human Biology and Anatomy
박수병 ( Park Soo-Byung ) - Pusan National University School of Dentistry Pusan National University Hospital Department of Orthodontics
( Maki Koutaro ) - Showa University School of Dentistry Department of Orthodontics
( Kimur Ryosuke ) - Showa University School of Dentistry Department of Orthodontics
KMID : 0361920140440020096
Abstract
Objective: A recent study suggested that rs6504340, a polymorphism within the homeobox B (HOXB) gene cluster, is associated with the susceptibility for malocclusions in Europeans. The resulting malocclusions require orthodontic treatment. The aim of this study was to investigate the association of rs6504340 and other dentition-implicated polymorphisms with dental and occlusal traits in Korean and Japanese populations.
Methods: The study participants included 223 unrelated Koreans from the Busan area and 256 unrelated Japanese individuals from the Tokyo metropolitan area. DNA samples were extracted from saliva specimens. Genotyping for rs6504340 and four single nucleotide polymorphisms (SNPs) that have been shown to be associated with the timing of first tooth eruption and the number of teeth at 1 year of age (rs10506525, rs1956529, rs9674544, and rs8079702) was performed using TaqMan assays. The Index of Orthodontic Treatment Need (IOTN), overjet, overbite, arch length discrepancy, crown sizes, and length and width of the dental arches were measured. Spearman’s correlation coefficients were calculated to evaluate relationships between rs6504340 and these dental/occlusal traits.
Results: We evaluated the aesthetic components and dental health components of the IOTN in the Korean and Japanese populations and found that neither rs6504340 nor the other four SNPs showed any association with dental and occlusal traits in these East Asian populations.
Conclusions: These negative results suggest that further research is needed to identify the genetic determinants of malocclusions in order to reach a consensus.
키워드
Genetics; Tooth size; Tooth size; Orthodontic index
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